this post was submitted on 07 Jul 2025
1021 points (97.9% liked)
memes
16095 readers
3263 users here now
Community rules
1. Be civil
No trolling, bigotry or other insulting / annoying behaviour
2. No politics
This is non-politics community. For political memes please go to !politicalmemes@lemmy.world
3. No recent reposts
Check for reposts when posting a meme, you can only repost after 1 month
4. No bots
No bots without the express approval of the mods or the admins
5. No Spam/Ads
No advertisements or spam. This is an instance rule and the only way to live.
A collection of some classic Lemmy memes for your enjoyment
Sister communities
- !tenforward@lemmy.world : Star Trek memes, chat and shitposts
- !lemmyshitpost@lemmy.world : Lemmy Shitposts, anything and everything goes.
- !linuxmemes@lemmy.world : Linux themed memes
- !comicstrips@lemmy.world : for those who love comic stories.
founded 2 years ago
MODERATORS
you are viewing a single comment's thread
view the rest of the comments
view the rest of the comments
Anyone around here have actual experience with ozempic? My dr has actuality suggested it for a potential heart issue, to help clear up the system i guess. But everyone online talks about it like it’s heroine
It's more along the lines of: Could you benefit from it because of some legit medical issues. Then go ahead.
Do you want to take it recreationally to fit in your new dress for the wedding 3 weeks from now without any lifestyle changes? Don't take it.
Ozempic is not some fun new "weight loss shot", it's a fucking necessity for people with diabetes. That includes Type I diabetes, which is due to genetics and not lifestyle choices.
Recreational users have made ozempic scarce, raising the price to unsustainable levels for folx that rely on it to stay alive
You're right except the last point - all drug shortages and issues are the result of doctors/public health and drug manufacturers. Never patients. It is a lie they tell us so we blame ourselves and each other.
Patients can't write their own prescriptions. Patients can't magically procure a drug in their hands. They aren't stealing them from diabetics, they are being advertised to and buying the product.
My ex was on it for diabetes, and it caused gastroparesis in him and he ended up hospitalized for 12 days. His digestion has never been the same, and he's in a class action lawsuit against the makers of Ozempic because it's a side effect that they didn't disclose.
Before going on Ozempic, read up on current medical research (not Facebook or such shit). They discovered some not-so-good long term effects recently.
Like many medications, you are balancing the risks of continuing with an unmedicated health problem or any negative side effects of the medication.
But with Ozempic there is some serious long-term shit going on, which is bad, as you basically have to take this stuff forever or bounce back hard faster than you saying "supersize this burger meal".
It hospitalized my ex for 12 days. The side effects are real. He's in a class action suit against the company.
I think most medications are meant to be accompanied with permanent lifestyle changes where possible. No, you should not take this drug “forever”. If you take ozempic for weight loss but choose to continue eating like shit then it isn’t the drug’s fault. Assuming of course there isn’t some other medical disorder leading to weight gain, but again, balancing the negative health effects of obesity vs any negative effects of weight loss drugs needs to be examined by patient and physician.
That's not how it works. Ozempic simply opresses the hunger feeling, therefor helping you lose weight. Problem is that still existing, but empty/depleted fat cells basically scream "we are hungry", so as soon as you get off Ozempic, you basically can't stop eating until you regained at least the former state. That was - for me - the reason not to start on Ozempic, it's like the "bounce back" effect after a diet, but on steroids. That current research has found other issues (heart problems, ocular nerve damages) just enforced my rejection (I was offered this on a free prescription base).
That is a very idealistic view, at least on some medication. With Ozempic, this is basically impossible due to the circumstances written above, with other medications it is simply due to the fact that no "lifestyle changes" can change e.g. genetic defects.
You completely ignored the “permanent lifestyle change” aspect. It doesn’t matter whether the person in need of weight loss does it via diet and exercise or via diet and ozempic, the diet/lifestyle that they got themselves fat on has to change.
You’re basically blaming the drug for the person’s inability to psychologically deal with diet. That isn’t what the drug does. No, you don’t need to eat back to your old weight, that’s the part where permanent change to diet comes in.
I already stated a caveat for conditions that may be outside the user’s control, so don’t use that as an excuse for all users. Yet again, the doctor and patient have to discuss the risks. I’m done here.
No, I don't. I'm just stating facts on how the human body works. With extreme willpower you might be able to counter this for a time, yes. But it will be a serious uphill battle, and the messenger chemicals from the depleted fat cells do not just stop because you will them to. You will just have to live in a state of perpetual raving hunger then. The few who can successfully overcome this for a significant time are rare, indeed.
I’m down 100lbs and been chilling there for a a while actually. (I do bulk/cut cycles of around 30lbs for bodybuilding so my total weight loss fluctuates from like 120lbs to 90lbs depending on how that’s going. Just for disclosure)
But I’ve heard a few people mention this idea that “fat cells stick around forever” and “send hunger signals to fill you back up”. Do we have a scientific source for this?
My other thing with it is like, that’s not the reason someone gets fat the first time right? Because the idea is your fat cells start multiplying after a certain weight? So regardless it still seems important to address that first cause and not repeat it
But for me personally I just haven’t really experienced it at all lol. I’ve found that actually the type of food I eat makes me hungry and more likely to go off track. Like any fast food, most prepackaged snacks and prepared meals from the grocery store.
Like I could eat an 800cal pint of ice cream then have dinner 45 minutes later. But 200 calories of frozen grapes and I’m like, stuffed lol. Or I’ve also noticed if I have a doughnut in the morning (work offers them) I’m hungry all day, but eggs cheese oats and yogurt leave me satisfied to the point where I’m not hungry at all when I get home, and eat just because I know I need the nutrition from dinner.
Anyway sorry for rambling, really I’m just curious to get to the bottom of the “depleted fat cell” thing. I had never heard of it the entire time I was losing weight/maintaining then all of the sudden I’m hearing it pop up in lots of places, even lemmy now
Because hunger has to do with vitamin balancing and a lot of people don't get enough of certain vitamins which keeps them always behind.
Eg vitamin A makes your skin slough off in excess and can kill you in very high doses. To treat high vitamin a in the ER, doctors use vitamin e. Vitamin E can make you bleed in excess if you have a deficiency of vitamin K, so vitamin e excess is treated with vitamin k. Vitamin e deficiency can also cause blood clots. Vitamin D interacts with all of the above as well and they actually all interact with each other and make uo a large part of the immune system with downstream effects on other vitamins including b vitamins.
For a lot of people, once they understand how to balance their vitamins, they dont feel hungry anymore. But people alwyas want a magic pill that splves everything instead
https://pubmed.ncbi.nlm.nih.gov/29991030/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4371661/
This one's not as easy for me to quote.
Basically the gist of the whole idea is that your body maintains the level of fat cells pretty steadily as an adult. When you gain or lose weight the cells just grow or shrink, but they can only grow so big before you need new cells to store more energy and your body will build them. Each of the fat cells have a part to play in signaling that you're in a deficit and need to consume more calories (when we didn't have such calorie dense foods readily available this was probably correct most of the time). So, if you have 2 or 3 times the number of fat cells then you "should" that's increasing the signaling you receive to eat, making it harder not to (simplifying that a lot). In normal maintenance, your body still maintains that turnover pretty steadily so it generally doesn't go away.
I’ve read the first study already, it doesn’t comment at all on the hunger signaling aspect.
The second study is just proposing this as a mechanism which may account for weight regain. They spin off pretty quickly into a more matter-of-fact tone while presenting the hypothesis itself, but at the moment it remains speculation. I obviously haven’t had the time to click through to every reference in there, but so far the links I have checked similarly lead to speculation.
Basically I think it’s somewhat dishonest to present this hypothesis as a statement of fact. I feel like the inevitable result of this mischaracterization will cause people to not even try. Why bother if something is probably impossible, or only one in a million could do it?
Thank you for linking it however, and I will be very interested to know if Professor MacLean verifies the concept. Of note, in the conclusion they propose that environmental and behavioral interventions will be important for combatting this effect, if it does turn out to be true
You're right the second article probably doesn't support the hunger bit enough. As i understand it, the hunger signaling is largely an absence of leptin, which is a hormone that regulates appetite. The increase in fat cells from obesity leads to more leptin production and then leptin resistance, so it's less effective. When you diet and lose the weight the fat cells aren't producing as much leptin and you're resistant to what they are producing so you're comparatively hungrier than you may have been if you stayed at a healthier weight. I believe the leptin sensitivity can recover and be improved through other ways but I'm not an expert.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6354688/
Thank you again for the link, but it seems like you’re just reiterating the hypothesis without any supporting evidence? We have a proposed mechanistic explanation for the phenomena that requires further study. My point of contention is that it should be presented as such, and not as a granted fact
The "fat cells are multiplying" is normal when having surplus calories in the body. The "empty fat cells scream hunger" is something that was suspected basically for ages, but has finally be proven not long ago, the paper is less than half a year old. It had been referred to here on Lemmy, at least to a science or nature article that pointed to the paper.
Could you direct me to the paper where it was proven? There seems to be a notable amount of bad journalism and broad misrepresentation of the science on this topic.
We are basically discussing whether or not obesity is an inescapable condemnation, so we should not sensationalize the topic whatsoever, and we should especially not present it as a fact if it is not a fact
I've seen several successes and I wouldn't believe every story you hear in these forums. The data shows it's relatively safe with minimal serious secondary effects. That doesn't mean nothing to manage at all. Just like statins for cholesterol.
Ozempic and variants are also considered short term. They essentially short circuit the desire for vices, but are only effective for about a year. You either relearn your habits or you'll eventually revert. If you are in ozempic for 2 years on weight loss you've likely ignored your doctor.
I'll bite. I'm on it for what some people here would consider "recreational" purposes (weight loss). However, I have polycystic ovaries and have had extreme difficulty losing weight in other ways. Essentially the only way I can lose weight is doing a pretty severe calorie deficit, which is really hard to do and essentially means I am starving all the time. Ozempic has helped me curb that perpetual feeling of hunger, and besides diarrhea (which I already had often anyway), it hasn't caused me that many side effects.
Essentially PCOS causes a craving for carbs and sugar. It's hard to fill that hole, but there are other ways to supplement the things that my body is not creating which make me crave those things. While I'm on ozempic (I don't plan on using it long-term) I'm also working to make changes to my diet to make sure I'm getting those things I was missing (B12, chromium picolante, some other stuff with scientific names).
And I know people think it's just "lazy", which it is for some people, but I struggle to lose weight even with exercise and calorie deficits. Ozempic has helped me lose some, but not as drastic as other people.
I have friends who are on waygovy (the same drug as ozempic but specifically targeted at weight loss) and they've had more side effects than me, but they are significantly bigger, have less healthy lifestyles and are I believe on a much higher dose than me. They've lost a ton of weight though.
I’m basically at the line of pre diabetic so the doc wants something to jumpstart me off the line, i definitely need to make changes but I would love the help to get going. I tend to intermittent fast but when I do eat it’s junk. Most people don’t get it but it’s akin to any addiction. Most times you don’t realize you’re binging till after, so something that can kill my cravings would be lovely
I haven't done the type of deep dive research others mention here but I trusted my doctor when he told me this was a good choice for me. I also don't live in the US so have no reason to believe he's being paid off. If there are worse consequences than what I've discussed with him already, I guess I'll have to deal with that.
There are also non-medicinal ways to treat binge eating, and I've known people that have had good success with therapy/CBT for that, in case that's something you can afford or are interested in.
My wife has been on wegovy for about 3 months now, which is supposed to be similar. It's ok, I guess. Still ramping up to the full amount and there was one week of really bad digestion issues, but the rest has been fine. She feels full way quicker, and if you go over that amount, you start to feel nauseous, so you stop. Problem is she hasn't really done much else to help it. Still eating the same and hasn't introduced more exercising to help. So far, loss is around 15 lbs, but it's kind of sitting steady around this for a bit now.
Try to get her to eat vitamin k1 and/or k2 if you can. It will help her feel like exercising and moving more
Thanks, I'll use that for my own knowledge!
I'm on Mounjaro for diabetes, have lost 35 pounds in two months. It's a tool, with potential side effects, but for me it has been a huge jump-start for a lot of neglected health issues and overall energy levels.
I've never taken Ozempic, but I did used to be a pharmacy tech, and having to tell patients that it was unavailable due to supply issues, on a daily basis, really sucked. I'm sure it was much worse for them.
Ozempic can be the right choice, but it's good to do plenty of research, and if you can, prioritize lifestyle interventions first. Here's a video series on Ozempic, as well as ways that you can stimulate glp-1 production naturally through diet and lifestyle-
https://m.youtube.com/playlist?list=PL5TLzNi5fYd90bMuM9SuzQ83E1IsM3Yy4
I've been on tirzepatide for maybe three months at this point. I highly recommend it. I think the risks are massively overblown. It's predictable fear-mongering that is simply an understandable reaction to how greedy the pharma companies are with their pricing on it. If you can't afford it, it's tempting to convince yourself it would be a bad thing to take it anyway.
I can't afford it, but instead of spreading FUD about it, I found a third way. I just pirate the shit out of it! I'm not just taking tirz, I'm taking bootleg tirz! So far I've dropped from about 180 to 150.
My ex is on one of those for blood sugar. She’s not losing weight but she said it made a significant difference controlling her blood sugar.
On the other hand her Dad is also on one of those for blood sugar but he’s never hungry and forgets to eat for days so has lost too much weight. It’s to the point where the doctor said anything he wants, load him up on chips and ice cream if necessary to get him back to a healthy weight
Im like 190lbs and have high blood sugar. I see guys twice my size eating cheeseburgers and they don’t get it. Doctor told me it’s generic for me, but it doesn’t help that I smoke weed and eat all my kids cereal at 1am
You might want to consider keto or low carb. It will help with your blood sugar.
I remember seeing this video where someone tearfully explained they got osteoporosis from being on it for a year.