this post was submitted on 20 Dec 2025
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[–] KingOfSuede@lemmy.world 159 points 1 day ago (1 children)

Salient points for those who don’t want to read the article, or can’t:

  • The team administered a single shot of E. americana intravenously to mice with colorectal cancer, and it completely eliminated tumors in every treated animal.

  • Caused only short-lived inflammatory effects that resolved within 72 hours

  • Over two months of observation, treated mice showed no signs of organ damage or chronic toxicity.

  • The bacterium are also sensitive to antibiotics, providing intervention options if problems were to arise following treatment.

  • When the mice were later re-exposed to cancer cells, none developed new tumors, suggesting the treatment had triggered long-lasting immune memory.

This holds some real promise, I’m very excited to see what this brings! Kudos to the researchers!

[–] UltraBlack@lemmy.world 18 points 1 day ago (2 children)

Mfw bacteria become resistant: 😱😱😱

[–] BuboScandiacus@mander.xyz 15 points 1 day ago (2 children)

Still probably better than cancer, no ?

[–] musubibreakfast@lemmy.world 6 points 1 day ago

Yes, now you have to shove a live frog up your ass every day or die of colon cancer.

[–] UltraBlack@lemmy.world 3 points 1 day ago (1 children)

Multiresistant bacteria are a death sentence in many cases...

[–] IAmNorRealTakeYourMeds@lemmy.world 2 points 1 day ago (1 children)
[–] acockworkorange@mander.xyz 1 points 20 hours ago

In many cases it isn't.

[–] RVGamer06@sh.itjust.works 2 points 20 hours ago* (last edited 20 hours ago)

Le epic bacteriophage:

[–] zakobjoa@lemmy.world 60 points 1 day ago (4 children)

Just a minute at 2000°C also eliminated all cancer cells in mice.

[–] First_Thunder@lemmy.zip 37 points 1 day ago (2 children)

Impact on the remaining cells still requires further studying

[–] Test_Tickles@lemmy.world 18 points 1 day ago

It turns out that the witch who turned the prince into a frog was actually curing his cancer not cursing him.

[–] BootLoop@sh.itjust.works 2 points 8 hours ago

That is outside of the scope of this study however.

[–] MonkderVierte@lemmy.zip 21 points 1 day ago (2 children)
[–] bdonvr@thelemmy.club 8 points 1 day ago (1 children)

Did we read the same paper? Not a single case of regression after treatment.

[–] XM34@feddit.org 5 points 1 day ago (2 children)

They were talking about the downsides of treatment via 2000 °C.

[–] bdonvr@thelemmy.club 5 points 1 day ago (1 children)

Yeah so was I. But they're wrong, like I said no specimen had cancer return after the 2000⁰C treatment.

[–] jmill@lemmy.zip 3 points 1 day ago

True, but by a different mechanism. Immune memory was not involved in their continued resistance.

[–] MonkderVierte@lemmy.zip 1 points 1 day ago

oh, the immune system will remember, all your cells will remember

[–] TypFaffke@feddit.org 18 points 1 day ago* (last edited 1 day ago)

Ah yes, Thermotherapy

[–] Engywuck@lemmy.zip 2 points 1 day ago

I bet I can do the same in under 10 s.

[–] RacerX@lemmy.zip 23 points 1 day ago

Awesome!

... we'll never hear about this again.

[–] Konstant@lemmy.world 22 points 1 day ago

Getting news from memes is next level.

[–] lurch@sh.itjust.works 20 points 1 day ago (2 children)

afraid to ask: did it also eliminate the mice?

[–] ElderReflections@fedia.io 41 points 1 day ago

What's more, the response wasn’t just rapid but appeared to provide ongoing protection. When the mice were later re-exposed to cancer cells, none developed new tumors

Apparently it made them stronger

[–] Manjushri@piefed.social 7 points 1 day ago (1 children)

Quite the contrary...

first, it has a natural affinity for the low-oxygen environment inside solid tumors, so within just 24 hours it had increased its numbers by around 3,000-fold, but it also didn't drift over to impact any other healthy organs or tissue. Then it's able to directly kill the growth thanks to toxins it secretes inside the tumor.

At the same time, the bacterial invasion triggered a natural immune response, and the tumors soon became flooded with immune cells – particularly neutrophils, and T and B cells – alongside increases in inflammatory signaling molecules. The combined effect was widespread tumor cell death driven both by direct bacterial action from the foreign gut bug and by the host’s own immune system.

...

Importantly, this mechanism appears to also be highly tumor-specific, with E. americana sticking only to the tumor environment. The researchers believe this selectivity arises from a combination of factors unique to tumors – insufficient oxygen (hypoxia), leaky blood vessels, altered metabolism and locally suppressed immune defenses that allow the bacterial colony to thrive where they are also most destructive.

[–] untorquer@lemmy.world 2 points 20 hours ago

Shit thats a lot of promising routes of action and modulation.

[–] Deestan@lemmy.world 19 points 1 day ago
[–] SaharaMaleikuhm@feddit.org 11 points 1 day ago (2 children)

Do I eat frog poop or should I suckle on their anus for best results?

[–] falseWhite@lemmy.world 11 points 1 day ago

"when administered intravenously", so you inject their poop

[–] pewpew@feddit.it 1 points 1 day ago* (last edited 1 day ago)

Neither. Vore time

[–] shalafi@lemmy.world 9 points 1 day ago (1 children)

This is my argument for government science budgets.

Headline: Scientists Spend Millions Studying Andean Frog Fucking Habits!

"What a waste!"

What if I told you those scientists were making more frogs to study how they can freeze solid and thaw out? Or how limb regeneration works?

Practically all meds come from science like that.

why are you studying Easter island soil? discovery of Rapamicin and the cell cenesense pathways in human cells.

[–] Luvs2Spuj@lemmy.world 8 points 1 day ago (1 children)

If this takes off it could be a great thing for conservation. Frogs are in a lot of trouble!

Sadly I'm not so sure, but I like to be optimistic

[–] untorquer@lemmy.world 3 points 20 hours ago

If this ~~takes off~~

Leaps off

[–] West_of_West@piefed.social 7 points 1 day ago

Gale: Stop licking the damn thing!

[–] NigelFrobisher@aussie.zone 4 points 23 hours ago

They needn’t worry unless the mouse experimental animal Union is more powerful than theirs.

[–] thenewred@lemmy.world 1 points 1 day ago

:bufo-offers-gut-bacterium:

[–] robocall@lemmy.world 1 points 19 hours ago

I am down to get some frog gut shots