this post was submitted on 07 Jul 2025
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[–] Treczoks@lemmy.world 3 points 3 days ago (42 children)

But with Ozempic there is some serious long-term shit going on, which is bad, as you basically have to take this stuff forever or bounce back hard faster than you saying "supersize this burger meal".

[–] RememberTheApollo_@lemmy.world 4 points 3 days ago (35 children)

I think most medications are meant to be accompanied with permanent lifestyle changes where possible. No, you should not take this drug “forever”. If you take ozempic for weight loss but choose to continue eating like shit then it isn’t the drug’s fault. Assuming of course there isn’t some other medical disorder leading to weight gain, but again, balancing the negative health effects of obesity vs any negative effects of weight loss drugs needs to be examined by patient and physician.

[–] Treczoks@lemmy.world 4 points 3 days ago (34 children)

If you take ozempic for weight loss but choose to continue eating like shit then it isn’t the drug’s fault.

That's not how it works. Ozempic simply opresses the hunger feeling, therefor helping you lose weight. Problem is that still existing, but empty/depleted fat cells basically scream "we are hungry", so as soon as you get off Ozempic, you basically can't stop eating until you regained at least the former state. That was - for me - the reason not to start on Ozempic, it's like the "bounce back" effect after a diet, but on steroids. That current research has found other issues (heart problems, ocular nerve damages) just enforced my rejection (I was offered this on a free prescription base).

I think most medications are meant to be accompanied with permanent lifestyle changes where possible. No, you should not take this drug “forever”.

That is a very idealistic view, at least on some medication. With Ozempic, this is basically impossible due to the circumstances written above, with other medications it is simply due to the fact that no "lifestyle changes" can change e.g. genetic defects.

[–] jet@hackertalks.com 1 points 2 days ago

empty/depleted fat cells basically scream “we are hungry”, so as soon as you get off Ozempic, you basically can’t stop eating until you regained at least the former state.

I don't think that is quite right. If people on Ozempic use the opportunity to adapt to a low carbohydrate diet, when they come off the drugs they won't be suffering from the save sugar craving addiction cycle.

Fat cells don't scream "we are hungry" they scream "we are full" that is what leptin signaling is for, but carbohydrate addiction is a much stronger signal for many people.

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