this post was submitted on 14 Mar 2025
1653 points (96.7% liked)

Science Memes

13323 readers
3679 users here now

Welcome to c/science_memes @ Mander.xyz!

A place for majestic STEMLORD peacocking, as well as memes about the realities of working in a lab.



Rules

  1. Don't throw mud. Behave like an intellectual and remember the human.
  2. Keep it rooted (on topic).
  3. No spam.
  4. Infographics welcome, get schooled.

This is a science community. We use the Dawkins definition of meme.



Research Committee

Other Mander Communities

Science and Research

Biology and Life Sciences

Physical Sciences

Humanities and Social Sciences

Practical and Applied Sciences

Memes

Miscellaneous

founded 2 years ago
MODERATORS
 
you are viewing a single comment's thread
view the rest of the comments
[–] OsrsNeedsF2P@lemmy.ml 24 points 2 days ago (10 children)

Can someone explain to me how some XX people become cis male?

[–] match@pawb.social 75 points 2 days ago (2 children)

https://en.wikipedia.org/wiki/XX_male_syndrome

tldr biology is dice rolls and humans are intersex for no reason sometimes

on a side note one of my friends had this and she only found out when she started transitioning. she is now a trans woman with XX chromosomes. i can only imagine how fucking vindicating it must have felt

[–] Skullgrid@lemmy.world 8 points 1 day ago

tldr biology is dice rolls and humans are intersex for no reason sometimes

To make involuntary non-cis , non-het , infertile aunts and uncles.

[–] bleistift2@sopuli.xyz 6 points 1 day ago (1 children)

WTF is going on on that article’s Talk page? Are teachers now assigning students to edit Wikipedia articles and have others “peer review” them?

[–] forrgott@lemm.ee 40 points 2 days ago

Gene expression is not as straightforward as people think. All sorts of weird shit can happen, and that's not even including gene mutations.

[–] ragebutt@lemmy.dbzer0.com 40 points 2 days ago

De La Chappell syndrome, congenital adrenal hyperplasia, androgen exposure in utero, ovotesticular disorder of of sex development all result in a person with cis male characteristics and in some cases cis male typical genitalia despite having xx chromosomes

[–] evasive_chimpanzee@lemmy.world 25 points 2 days ago* (last edited 1 day ago) (1 children)

https://static.scientificamerican.com/sciam/assets/File/Pitch_sketch_final.png?w=2000

This is the best resource I've seen to show things relatively simply.

The TL;DR is that a whole "Y" chromosome isn't exactly responsible for "maleness", the SRY gene is. It's normally on the Y chromosome, but mutations can occur placing that gene onto the X chromosome. Inversely, someone could inherit a Y chromosome without that gene, in which case they would develop with female traits.

It's not considered trans because someone with 46XX plus the SRY gene would develop male genitalia, be identified as male at birth, and likely identify themselves as male. For some types of these conditions, there are plenty of people walking around with no clue that their chromosomes don't match their gender.

Disclaimer: I'm not a geneticist, so i could have explained something a little off.

[–] Lemminary@lemmy.world 1 points 1 day ago

I'm also not a geneticist but I did study genetics for a while and that's pretty much what I remember learning, so you're good.

The books Mutants: On Genetic Variety and the Human Body by Armand Marie Leroi explains it all very well and touches on many other related genetic conditions like the Klinefelter syndrome (XXY). It's an incredible read all around that really opened my eyes to how malleable biology is.

[–] OmnipotentEntity@beehaw.org 22 points 2 days ago* (last edited 2 days ago)

I googled it for you.

https://en.wikipedia.org/wiki/XX_male_syndrome

In 90 percent of these individuals, the syndrome is caused by the Y chromosome's SRY gene, which triggers male reproductive development, being atypically included in the crossing over of genetic information that takes place between the pseudoautosomal regions of the X and Y chromosomes during meiosis in the father.[2][7] When the X with the SRY gene combines with a normal X from the mother during fertilization, the result is an XX genetic male. Less common are SRY-negative individuals, those who are genetically females, which can be caused by a mutation in an autosomal or X chromosomal gene.[2] The masculinization of XX males is variable.

[–] Didros@beehaw.org 18 points 2 days ago

You've heard of xy people and xx people, but wait till you hear about X people!

Or xxx people, or xxy people, or... dies

[–] Lucky_777@lemmy.world 5 points 2 days ago

Maybe she means the exceptions?

Exceptions: While XX and XY are the most common sex chromosome combinations, there are exceptions, such as individuals with variations in their sex chromosomes, such as XXY (Klinefelter syndrome) or XYY.

[–] gratux@lemmy.blahaj.zone 4 points 1 day ago

cis just means your current gender identity is the same that was assigned to you at birth. there are cases where someone has XX chromosomes, but the body develops as male.

[–] Binette@lemmy.ml 3 points 2 days ago

Outward, their genitals might look like those of the oposite sex.