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Everything has to be perfectly sterile anyway, this is cell culture. Open tops STRs are not exactly a thing. It doesn't have to be pharma grade, sure, but food safety is a thing and you're not going to get a process certified without it. Main issue remains to be the cost of medium, serum-free or not.
I do wonder where you got that idea from, though. I don't intend to be rude, but have you got any kind of experience in the field?
Yeah that's the problem... farms don't have to be sterile. scaling that up has proven to be almost impossible. Cost of the medium is just one of the problems
I am very interested in the topic and follow it closely, here's a recent video on the topic summarizing the problem made by a food scientist
https://www.youtube.com/watch?v=ZPCnVwwENaQ