Let's assume that the Axis winning the war means they keep all territory they've had at the height of their expansion in our timeline but don't expand much more, at least not immediately.
- The EU does not exist but as most of Europe is either occupied by Germany or allied with it, there might be a similar organization with a way stronger Germany at its center.
- If a NATO-like alliance forms, it excludes most of Europe, mainly consisting of the USA, Canada and UK, maybe Spain and Portugal
- The Soviet Union is way weaker than in our timeline with most of Eastern Europe being under German control. They still have control over Central Asia, probably more than in our timeline.
- The Allies still control Gibraltar and are able to intercept ships passing through the English Channel, making the west of France the only safe access to the Atlantic for the Axis.
- Wernher von Braun and other rocket scientists stay in Germany, giving the USA and Soviet Union a massive disadvantage in the development of ICBMs. The USA may have nuclear bombs but their only way to threaten Germany with them would be UK-based bombers which are way slower and easier to defend against. On the other hand, a failure of the Manhattan Project might be the whole reason why the Axis wins the war. Everyone will figure it out eventually but as we see from real life, it might take decades.
- No proper cold war as there are no two super powers exercising mutually assured destruction with ICBMs but probably ongoing tensions along the German-Soviet border. The USA probably stays out of it to avoid becoming a target for either side.
- Italian East Africa (Somalia) becomes the most important rocket launch site in the world, as it is the only Axis-controlled territory that is close to the equator and has open ocean to the east. Some smaller rockets may launch from Japan. French Guiana might be under Axis control but shipping rockets over the Atlantic is dangerous when they could get intercepted by foreign ships. Without competition, manned spaceflight develops a lot slower, maybe not at all.
- Without manned spaceflight and the threat of a nuclear war, there is less incentive to develop computers and the internet.