science

I looked into genetic factors of centurions out of curiousity before and it does largely seem to be nature rather than nurture. Centurions tend to have siblings that are also centurions, both of whom typically have overactive telomerase enzymes. Apparently some type of enzyme that prevents aging of cells. Theoretically, if those same people avoided alcohol and cigs their whole life, they would have lived even longer.

Their brains are literally wired wrong. They will not learn empathy, but assume they are capable of more than they are.

The (US) government has a long history of outlawing useful, helpful or otherwise enjoyable things (MDMA, weed and psilocybin) while allowing more destructive things to proliferate (alcohol, opiates). Many governments worldwide still outlaw marijuana and some places will straight up execute people for it (singapore). Keeps the population in check and helped fuel conflict within the lower class to keep them from looking upward.

So how is a psychedelic pulling this off? The secret could be serotonin receptors found throughout the body, not just in the brain. When activated, they seem to trigger a cascade of effects that reduce stress, preserve DNA, and promote long-term cell health.

They're talking about psilocin's activity at serotonin receptors, I'm pretty sure

If you do happen to find it, please post a link. I'll go looking also.

Never mind. It was linked in the article.The paper in question.

I have the opposite little thought in the back of my mind. Knowing that my life will end one day gives me the energy to keep going. If I had to live forever, I would need a few 100 year naps or I'd go insane.

Like if I die and "wake up" in the afterlife and I gotta keep existing. Fuck that. Send my energy back to the source and let it just vibrate.

Nope.

Why beg for something that is impossible and likely to add to my pain later in life? I see no reason to hold onto that dream or to beg for it.

I don't understand what is worth sticking around indefinitely for either when it's the fact that the present is slipping by so quickly for so many. You don't get it back for living longer.

Sex every day? U lucky bastid

But I'd argue you can lead a meaningful life with knee pain and far sightedness.

My back started hurting at 25, I hadn't even had a job yet.

i want to outlive the last fascist

To evaluate the impact of psilocybin on longevity in vivo, aged (19 month) female mice were treated with vehicle [vehicle is what the psilocybin was suspended in for injection] or psilocybin [actually vehicle + psilocybin] once/month for 10 months; mice were initially given a low-dose (5 mg/kg) for the first treatment followed monthly high-dose (15 mg/kg) treatment for a total of 10 treatments. We elected to utilize 19-month old mice, which is roughly equivalent to 60–65 human years, in order to evaluate its therapeutic potential as a clinically-relevant anti-aging intervention.

Within 30 min post-treatment, mice exhibited increased head-twitch response, which is a well-established behavioral indicator of hallucinogenic impacts of psilocybin in mice. Both psilocybin and vehicle groups exhibited some loss in body weight from the start to end of the treatment protocol, however weight loss was not significantly different in vehicle vs. psilocybin-treated mice. Notably, psilocybin treated mice demonstrated significantly higher survival (80%), compared to vehicle (50%).

Although not quantitatively measured, psilocybin-treated mice exhibited phenotypic improvements in overall fur quality, including hair growth and reductions in white hair compared to vehicle-treated mice.

In summary, we provide the first experimental evidence demonstrating that psilocybin treatment can enhance survival in aged mice.

So, caveats:

• This is the first study; while further studies may show a similar result, we won't know for sure until they are completed. This could be a fluke. This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
• This was neither a double blind nor a placebo study; it is possible things like researcher impacts could influence the outcomes.
• Typical doses for psilocybin are 0.2–0.4 mg/kg in therapeutic settings, 4mg/kg for microdosing, to up to 20 mg/kg to be legitimately tripping; like the mice, if you use this regimen you will need to set aside a day to be tripping once a month, and after 10 months take a heroic dose and have a really big trip. Not impossible to arrange for many people, but this is not a regimen you can do while completely going about your regular day-to-day.

TLDR: Promising results in an under studies area. More studies are required to confirm results. Following this regimen will cause a non-trivial disruption in your monthly routine.