this post was submitted on 04 Nov 2025
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Showerthoughts
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A "Showerthought" is a simple term used to describe the thoughts that pop into your head while you're doing everyday things like taking a shower, driving, or just daydreaming. The most popular seem to be lighthearted clever little truths, hidden in daily life.
Here are some examples to inspire your own showerthoughts:
- Both “200” and “160” are 2 minutes in microwave math
- When you’re a kid, you don’t realize you’re also watching your mom and dad grow up.
- More dreams have been destroyed by alarm clocks than anything else
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- If your topic is in a grey area, please phrase it to emphasize the fascinating aspects, not the dramatic aspects. You can do this by avoiding overly politicized terms such as "capitalism" and "communism". If you must make comparisons, you can say something is different without saying something is better/worse.
- A good place for politics is c/politicaldiscussion
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If you made it this far, showerthoughts is accepting new mods. This community is generally tame so its not a lot of work, but having a few more mods would help reports get addressed a little sooner.
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The crazy thing is we actually do have things that work in humans but not in mice. Mice are omnivores and are very different in terms of optimal energy state. They tend to run in glucose more easily than on fat and their whole biology is built to be small and fast, with short life spans.
Checking how DNA repair works in an animal which lives for maybe 2 years is great for understanding DNA repair in short lived organisms, but we have tk repair damage for 50 times as long. It is just so much more complex and requires such different tools when you switch from maybe 2 years to maybe 80 years, it really isn't sane to assume it will all carry over.
Now for an accute toxin, say tobacco, sure, some things work just fine. There is not a huge difference between humans and mice when subjected to cyanide or arsenic. Being crushed by a falling piano is going to kill both of us. But a chronic poison? That will take decades to kill? That is very different. We can shed cells in a different way to how they can. We have more mass to store things. We have more energy storage. We have bigger kidneys with more opportunities for filtering. We are different.
When we enter ketosis we have some fairly significant cancer responses. When we maintain fasting for 5+ days we have a fairly large bump in autophagy, a state where the body kills off and recycles damaged cells. This state can cause some types of cancer to be more obvious to our immune systems and allow the tumor to be attacked. In some cases otherwise inoperable tumors can be removed after shrinking them through fasting. This does not replicate in mice. So yes, some treatments (not cures because that doesn't really apply) do work in humans and not in mice.
The strongest risk factor of human cancer is age. Wild mice live 6-9 months.
Yep, and surviving longer increases cancer rates. Cancer used to be a death sentence, now it is far less so. Many cancers which were a short time from death at diagnosis are now routine to remove or fix. Others that were soon fatal have 5 year survival over 90%, and some are even higher.
We haven't cured cancer just like we haven't cured industrial accidents, but honestly, so few people are eaten by hungry machines and left disfigured that it is likely you know less than a handful. Not cured but reduced to a much more manageable level.