So many girls and women, from thousands of games, both famous both niche, I'll list some, otherwise I would never end, I like them more as full-fledged characters due to their background and attitudes.
Sengoku 3 (2001) - Okuni
Fallout - Tandi (Young), Cass (FNV),
FF8 - Edea Kramer\Ultimecia
FF7 - Scarlet
Silent Hill 2 OG - Angela
YuGiOh Card Games - Many female cards, Amazoness Archetype and Harpie Archetype especially
Breath of Fire Series: Deis
Ace Attorney Series: Kay Faraday, April May
Alpha Protocol: Sie
7th Dragon Series - Female Trickster
Wild Arms Series - Edna Warren
Dragon Quest Series - Maya and Menia
Guilty Gear - Dizzy, Jam,
FF9 - Lanì, Marilith
Megaman Battle Network - Lilly, Mrs. Mari,
Policenauts - Meryl (way better than her MGS incarnation)
Street Fighter Series - Mika, Elena, Ibuki
Fire Emblem Series - Echidna, Amalda, Titania, Lute, Nuibaba (Gaiden Remake), Ninian,
FF4 - Valvalis\Lamia\Arachne (introduction to Monster Girls)
FF10-2 - Berserker Yuna
Megaten Series - The female goddesses and daemons
Magical Drop Series - Empress, World
KOF Series - Shermie, Vice, Li Xiangfei,
Fighting Layer - Lan Yinghua
Fighter Destiny 2 - Adriana and Mei Ling
Shadow Hearts - Koudelka, Shania (especially her "Tatanka" spirit form)
Splinter Cell (OG Xbox) - Enrica Villablanca
Onimusha 2 - Takajo
Tenchu Shadow Assassin - Tagami
Metal Gear Series - Naomi Hunter, Venus, Teliko, The Boss
So many girls and women, from thousands of games, both famous both niche, I'll list some, otherwise I would never end, I like them more as full-fledged characters due to their background and attitudes.
Sengoku 3 (2001) - Okuni
Fallout - Tandi (Young), Cass (FNV),
FF8 - Edea Kramer\Ultimecia
FF7 - Scarlet
Silent Hill 2 OG - Angela
YuGiOh Card Games - Many female cards, Amazoness Archetype and Harpie Archetype especially
Breath of Fire Series: Deis
Ace Attorney Series: Kay Faraday, April May
Alpha Protocol: Sie
7th Dragon Series - Female Trickster
Wild Arms Series - Edna Warren
Dragon Quest Series - Maya and Menia
Guilty Gear - Dizzy, Jam,
FF9 - Lanì, Marilith
Megaman Battle Network - Lilly, Mrs. Mari,
Policenauts - Meryl (way better than her MGS incarnation)
Street Fighter Series - Mika, Elena, Ibuki
Fire Emblem Series - Echidna, Amalda, Titania, Lute, Nuibaba (Gaiden Remake), Ninian,
FF4 - Valvalis\Lamia\Arachne (introduction to Monster Girls)
FF10-2 - Berserker Yuna
Megaten Series - The female goddesses and daemons
Magical Drop Series - Empress, World
KOF Series - Shermie, Vice, Li Xiangfei,
Fighting Layer - Lan Yinghua
Fighter Destiny 2 - Adriana and Mei Ling
Shadow Hearts - Koudelka, Shania (especially her "Tatanka" spirit form)
Splinter Cell (OG Xbox) - Enrica Villablanca
Onimusha 2 - Takajo
Tenchu Shadow Assassin - Tagami
Metal Gear Series - Naomi Hunter, Venus, Teliko, The Boss
Chrono Trigger - Queen Zeal
Chrono Cross - Riddel, Steena, Leena, Janice,
SFEX - Sharon, Pullun,