Okay great. Now this stranger on the Internet would recommend not listening to that stranger on the Internet.
Do not take nitros oxide. Not only is it dumb as fuck, it literally gives you nerve damage, among many other side effects that anyone could find with a short simple search.
Weed and mushrooms are two of the best drugs on the planet and have minimal long term negative effects. I love mushrooms and it's all about dosage- how many grams and how strong is it per gram. NO it will not ruin your perception of other drugs. Acid is way stronger I'd recommend avoiding unless you have a whole week to recover.
Just vape weed or better yet take edibles and some mushrooms you should have near 0 negative physiological effects. Why tf would you do laughing gas you'll damage yourself what is this a street party in 2005 god damn. Not to mention just makes you act like a damn fool
Fuck Nancy Pelosi I swear to God