this post was submitted on 26 Nov 2025
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thats why the big 3 companies make different version insulin so they are effective at certain times of the day, or when you eat/
there are multiple short-acting and long-acting insulins because you can't patent other people's things, but now it's all off-patent. just take your stainless steel bioreactor and preparative HPLC, cook up a batch, wait ten years for biosimilar approval and you're good to go
because unlike with small molecule drugs, when cooking up generic biopharmaceutical there’s extra approval process that amounts to a tiny clinical trial https://en.wikipedia.org/wiki/Biosimilar this and type of economics of scale that there is with biologicals makes manufacture at large scale way more preferable. these requirements were loosened a bit over time