How many times is the FDA going to approve beta amyloid lowering drugs that have no benefit to disease? isn't lowering beta amyoid and not affecting disease just proof, in humans, that the beta amyloid hypothesis is wrong?

[–] AnyOldName3@lemmy.world 14 points 4 days ago (1 children)

Drugs like Lecanemab don't help in that they don't reverse the progression of symptoms, but they do help in that they slow down the progression of symptoms. You'd expect someone who was given the drug for a few months to have more of their cognative ability left than someone who hadn't had it, but they'd both be much worse than they were at the start.

[–] BremboTheFourth@piefed.ca 4 points 3 days ago

Yeah, and I'm not sure that a drug that reverses the symptoms is a realistic target anyway. As far as I'm aware, Alzheimer's ultimately kills neurons. They ain't coming back without a time machine. A treatment that stops degeneration is as good a goal as we're gonna get.

Like, if I lose a limb in a car accident, is it really fair to say that the intervention required to let me live on as an amputee didn't work, since it couldn't grow my limb back?

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