Selfhosted
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If you're in the US, your university already has an accessibility office, and they probably have at least advice and at best some fancy expensive software that does what you want.
Other countries might have the same. If not, you can try just using screen readers and such, though I don't have any recommendations myself.
The thing is, you need to make proper PDFs with properly structured content with proper metadata for screen readers to be able to access the content in the PDF in a logical and sane way. This is what the OP is tasked to do, and why they are looking for help. So I’m not sure what you mean by “try just using screen readers.”