this post was submitted on 02 Nov 2025
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I'm going to push back on OTC HRT because of the health risks. Supraphysiologic estrogen and testosterone can both have lethal side effects, so correct dosing and monitoring for health complications are essential components of trans healthcare.
Both are already OTC in most of the world, specifically most developing countries.
More importantly, you are applying an insane and bad-faith standard when assessing medication. ANY medication can have lethal side effects. Down a bottle full of Tylenol and you'll condemn yourself to a slow agonizing death of liver failure. Yet you can buy that shit at gas stations.
You answered the wrong question. You asked, "can HRT be dangerous?" Any rational person trying to form an unbiased opinion about it would ask, "is HRT of comparable risk to existing OTC medications?"
You can get lethal effects from nicotine, alcohol, bleach, ammonia, and many, many combinations of chemicals that are available with, at most, age verification.
I'm all for people educating themselves as much as they want, from whatever sources they trust, but bodily autonomy DEMANDS someone be able to direct their own medication, including gender affirming medication. Doctor-as-gatekeeper is, IMO, not as good a model as Doctor-as-confidant-and-educator.
DIY saved my life. I purchased bloodtests and monitored my own treatment. But it would have been a lot safer had I not needed to order estrogen online from a foreign supplier.